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U.S. to Vaccinate 500,000 Workers Against Smallpox
Sun Jul 7, 3:17 PM ET
By WILLIAM J. BROAD The New York Times
The federal government will soon vaccinate roughly a half-million health care and emergency workers against smallpox as a precaution against a bioterrorist attack, federal officials said. The government is also laying the groundwork to carry out mass vaccinations of the public a policy abandoned 30 years ago if there is a large outbreak.
Until last month, officials had said they would soon vaccinate a few thousand health workers and would respond to any smallpox attack with limited vaccinations of the public. Since 1983, only 11,000 Americans who work with the virus and its related diseases have received a vaccination, according to the Centers for Disease Control and Prevention ( news - web sites).
The plan to increase the number of "first responders" who receive the vaccination to roughly 500,000 from 15,000 and to prepare for a mass undertaking of vaccinations in effect acknowledges that the government's existing program is insufficient to fight a large outbreak.
The government's new vaccination safeguards come amid continued talk in Washington of war against Iraq, which terrorism experts suspect of maintaining clandestine stocks of the virus, as well as growing criticism of the government's limited plan. Only Russia and the United States have declared stocks of the virus.
A highly contagious disease, smallpox was declared eradicated globally in 1980, eight years after the United States stopped routine vaccinations.
Until its eradication, smallpox killed roughly one in three people who were infected but not vaccinated. Because immunity is believed to diminish with time, most people alive today are considered vulnerable to smallpox. But federal officials have long resisted the resumption of mass smallpox vaccinations, citing the probable risk of serious side effects, even death.
Last month, a federal advisory panel backed a plan for "ring vaccinations," in which health workers would isolate infected patients and vaccinate people in close contact with them, forming a ring of immunization around an outbreak and a barrier to its spread. In theory, such a strategy can work because the vaccine, if given within four days of exposure to the virus, protects people from the disease.
Some experts on infectious disease said the plan's main virtue was that it required little smallpox vaccine.
The government's more aggressive plans are possible because vaccine supplies are rapidly increasing as a result of crash manufacturing and stockpiling efforts begun soon after last fall's terrorist strikes, officials said. Also, studies have found that existing vaccine doses can be diluted without loss of effectiveness.
"Now we can act differently because we have more vaccine," Dr. Donald A. Henderson, senior science adviser to Tommy G. Thompson, the secretary of health and human services ( news - web sites), said in an interview. Dr. Henderson, who led the global smallpox eradication effort, added that in a crisis "we can make vaccine available on request throughout the community."
Officials said that about 100 million doses of the smallpox vaccine (160 million if diluted) are in hand and that by late this year or soon thereafter enough will be available for every American, more than 280 million people.
Health and military experts, citing new models of how the contagion can spread and new disclosures about how the weaponized virus can sail on the wind, have recently argued that limited, local vaccinations could produce thousands if not millions of needless infections and deaths. Most critics of the ring vaccination plan advocate mass vaccinations of the United States population but often before a smallpox attack, not after, as the government is now planning.
In addition to vaccinating more "first responders," the government plans to develop ways to speed vaccine deliveries around the country and help states plan how to carry out mass vaccinations after an attack.
Officials said the vaccinations of hospital workers and smallpox response teams, to begin fairly soon, would help train health professionals in smallpox vaccination and educate the public to the attendant risks.
The White House, Defense Department and other federal agencies are involved in the vaccination planning. "Everyone is aware," an administration official said.
Jerome M. Hauer, acting assistant secretary for emergency preparedness at the Department of Health and Human Services ( news - web sites), said the agency hoped to send planning documents on how to best conduct mass vaccinations to cities and states in the next week or two. Mr. Hauer added that logistics changes to that end were under way at the Centers for Disease Control and Prevention in Atlanta, which oversees the production, safekeeping and distribution of the nation's stockpile of smallpox vaccine.
Other details of the plans, such as who would receive peacetime vaccinations, have yet to be approved by Mr. Thompson, officials said.
In interviews last week, health officials said the government had not abandoned its longstanding plan for ring vaccinations of people near a smallpox outbreak, the approach health workers used decades ago to eradicate the highly contagious disease from human populations. But the added steps, officials said, will make it possible to move far more aggressively if a terrorist attack ends up infecting more than 100 people or so.
Critics had said the ring approach, while useful in battling natural outbreaks, would do little or nothing against a moderately skilled enemy intent on mayhem.
"Unless the initial attack is very small and the infectiousness of the agent is quite mild, ring vaccination is not going to do much good," said Edward H. Kaplan, a Yale public health specialist who questioned the method's value at a federal meeting in Washington three weeks ago.
In a report, the Cato Institute, a policy group in Washington, called ring vaccination "woefully inadequate for countering a direct attack."
Critics argued that a number of factors had diminished the method's effectiveness since the disease was eradicated in 1980: populations are now increasingly mobile, levels of immunity are very low and advanced technologies have become commonplace, raising the odds that a smallpox attacker would be at least moderately skilled.
"Today it's a totally different scenario," said William J. Bicknell, an international health expert at Boston University who recently faulted federal smallpox policy at a Cato meeting. The ring plan, he declared flatly in an interview, "will not work."
Federal officials said the rising criticism played no direct role in shaping preparations for mass vaccinations.
"The key to responding to any public health emergency is flexibility," Mr. Hauer said. "You listen to critics, but you can't let that drive policy. You have to do what's best for public health and national security."
Ring vaccination, he added, was envisioned as simply a first line of defense that could quickly expand to much wider immunizations if necessary.
Mr. Hauer added that the ring strategy was inherently small-scale because it required health professionals to carefully trace the whereabouts and contacts of infected people. Such work is so hard and time consuming, he noted, that ring vaccination is unsuitable as the only means of fighting a wide epidemic.
He said another complication could arise if the disease broke out simultaneously in multiple cities, suggesting a strike of unknown size and danger. In that case, he said, "the forces pressing you to mass vaccinate become greater."
Dr. Henderson, the chairman of the Secretary's Council on Public Health Preparedness at the Department of Health and Human Services, said critics have falsely portrayed the government as relying exclusively on ring vaccination.
"Let me be clear," he said. "If there is an emergency, and if we have to vaccinate widely, we need to be ready for it. That's what we're doing."
Mass vaccinations are not without risk because the smallpox vaccine uses a live virus, vaccinia, a cousin of smallpox, that on occasion can cause brain damage or even kill. In the days of wide vaccination, roughly one person in a million died.
The risk may be greater for people with weakened immune systems, like AIDS ( news - web sites) patients or people undergoing chemotherapy.
The government is seeking more supplies of vaccinia immune globulin, a substance now in short supply that can prevent severe reactions in people with immune problems as well as the healthy. Officials said 700 doses are in hand and 3,000 will be available by the year's end.
Despite the vaccine's well-known dangers, federal critics have increasingly called for various styles of mass vaccination including doing it on a voluntary or mandatory basis, before or after a smallpox attack.
At a June 15 public forum in Washington on federal smallpox vaccination policy, Dr. Kaplan, of Yale, presented a study done with colleagues from the Massachusetts Institute of Technology ( news - web sites) that described how a smallpox attack could affect a crowded metropolitan region like New York City. What began as 1,000 infections at a train station or airport, he said, would spiral over weeks and months into 97,000 deaths if fought with ring vaccination alone.
"By contrast," he said, "post-attack mass vaccination would result in only 525 deaths" from the smallpox virus, which takes about two weeks to develop in the body before symptoms become obvious.
Some federal officials call this study unrealistic. But at the meeting, such ideas gained force as new evidence came to light on how powdered smallpox can be used as a biological weapon.
Dr. Alan P. Zelicoff, a smallpox expert at the Sandia National Laboratories, reported that he and experts from the Monterey Institute of International Studies had linked a 1971 outbreak in the Kazakh Republic to a Soviet field test of weaponized smallpox.
Dr. Zelicoff, a physician, quoted a former Soviet official as saying the accident occurred when a plume of smallpox germs sailed about nine miles on the wind.
By the meeting's end, medical experts were questioning not only the ring plan but also federal assertions that the smallpox threat is low.
Dr. Kenneth I. Berns, president of the Mount Sinai Medical Center in New York City, said he judged the probability that Iraq possessed weaponized smallpox as "reasonably high" and that Saddam Hussein ( news - web sites) would use such germs in a war against the United States as "quite high."
"That's the confounding issue that we all face," Dr. Berns told the forum, according to a transcript.
Frank public discussion of the Iraqi threat, he added, "is absolutely essential."
In interviews, officials of the Department of Health and Human Services declined to comment on federal threat assessments but detailed wide contingency planning for mass smallpox vaccinations.
On June 20, a federal panel known as the Advisory Committee on Immunization Practices backed the idea of immunizing some emergency workers before any attack. Experts estimated that the immunizations would go to some 15,000 health care and law enforcement workers who would be most likely to respond to a biological attack and come in contact with victims.
But Dr. Henderson, the health department's senior adviser on bioterrorism, said the tentative new plan was for many more to be vaccinated. "We could easily be at a half-million without too much difficulty," he said.
Wide peacetime vaccinations, he said, would help educate not only the nation's medical community on the practical aspects of smallpox immunization but also the public.
If the peacetime group suffers a couple of deaths, "there will be a lot of publicity and concern," Dr. Henderson said. "It's a question of how people are going to respond."
-- (spoiled brat mass murderer @ must have. his way), July 07, 2002
The lives of American citizens are not real to a psychopath like Dumbya, and their deaths are just statistics, an acceptable consequence of his crusade to win the battle over the "axis of evil". He does not see this as blood on his hands, but blames it instead on the "big bad evil people". The most important thing to him is to make Mommy and Poppy happy before they die by killing the Evil Saddam and gaining control of all the oil in Iraq. Since he was raised a spoiled brat he does not know how to accept not always getting what he wants, so he will throw tantrums until he gets to finish "Operation Make Poppy Proud of Me".
-- (Dumbya@psychotic.manchild), July 07, 2002.
Sudan wanted to hand Osama Bin Laden over on a silver plate, but Clinton said "Osama who? Is that Metallica's new bass player?"
-- Yami Yogurt (email@example.com), July 07, 2002.
This reminds me of the story about the distribution of gas masks. Funny how Dumbya feels it is important to protect his family and certain high-ranking gubmint people, but leaves the rest of the "commoners" out in the dark.
-- lol (Dumbya@self-centered.bastard), July 07, 2002.
The Scientist July 8, 2002
Smallpox Vaccination: On Hold, But Lessons Learned
CDC panel recommends just starting with frontline personnel, not the general population
By Ricki Lewis
US citizens will not be lining up for smallpox vaccinations anytime soon, despite months of news reports on the stockpiling of enough vaccine for every man, woman, and child. On June 20, the US Centers for Disease Control and Prevention's Advisory Committee on Immunization Practices (ACIP), after evaluating information provided at public forums in New York City, San Francisco, St. Louis, and San Antonio, recommended to Tommy Thompson, secretary of Health and Human Services (HHS), not to vaccinate the entire population.1
"There was no compelling evidence that it would be appropriate to recommend it, given what we know about the threat level and the fact that there has been no disease since 1977," says David A. Neumann, director of the Alexandria, Va.-based National Partnership for Immunization, who served as a liaison representative to the committee.
Anthony Fauci, director of the National Institute of Allergy and Infectious Disease,2 William Bicknell, professor of international health at the Boston University School of Medicine and former health commissioner of Massachusetts,3 and others had requested the forums to debate whether vaccination practices to contain natural outbreaks of smallpox would translate into a setting of deliberate infection: bioterrorism. But leaders of the World Health Organization's (WHO) Global Smallpox Eradication Campaign, who worked in the trenches from 1966 to 1977, were unanimous that the strategies used then could work now, preventing deaths and illness from the live vaccine.
According to the recommendations, teams of specified first responders and medical personnel will be vaccinated ahead of time, "probably somewhere between ten and twenty thousand individuals," said John Modlin, chairman of ACIP on June 20. State or local governments will organize the teams. If an outbreak of smallpox occurs, the teams will implement "surveillance and containment through selective vaccination of contacts," new lingo for "ring vaccination," says Neumann. In the smallpox eradication effort, ring vaccination successfully identified and immunized contacts of cases, and the contacts of the contacts, ringing the outbreaks. This is possible because vaccinating within four days of ex-posure prevents symptoms. Recalls Don Francis, president of VaxGen in Brisbane California, "I was in the last outbreak in Europe, in Yugoslavia. We had to immunize the whole country, even outside the secondary and tertiary contacts. There was tremendous social concern, but it worked."
-- (glove is thrown @ copy n paste.waste), July 08, 2002.
-- (firstname.lastname@example.org), July 09, 2002.
Eeeeew, I'd never date a guy with that. Eeeeew!
-- (missy@club.X), July 09, 2002.