BBC Sunday, 12 August, 2001, 20:11 GMT 21:11 UK Briton 'cured' after CJD drug trial CJD is an incurable form of 'Mad Cow Disease' A British sufferer of variant Creutzfeldt-Jakob Disease (CJD) who underwent a pioneering drug treatment in America appears to have been "cured" of her symptoms.

Rachel Forber, 20, was diagnosed with vCJD, the human form of mad cow disease in June.

Miss Forber, who was given just a year to live, was confined to a wheelchair and could not recognise her parents as her condition degenerated.

But Nobel Prize winner Professor Stanley Prusiner conducted a new drug trial which transformed the health of the former soldier from Newton-le-Willows, Merseyside.

After just 19 days of treatment, Miss Forber was able to walk unaided, talk, use a knife and fork and complete co-ordination tests which were previously impossible, the Mail on Sunday reported.

First human tests

Miss Forber's mother Jane Taylor said the family had decided to go ahead with the treatment at the University of California School of Medicine as a last resort.

"At the end of the day we had nothing to lose because we were told that Rachel would die and we had everything to gain if this did work," she told Channel 4 News on Sunday.

"What they said was this treatment had only ever been done in test tubes in the laboratory and had never been tried on a human being."

The drug trials will bring hope to sufferers and their families - 99 people have died from the disease since 1996 and seven more suspected sufferers are still alive.

British officials have been in contact with Prof Prusiner's team and said they found the results promising, a Department of Health (DoH) spokesman said.

But he added: "Until the work is published and we have a chance to look at it properly, we cannot comment properly.

"It is a bit early to say it is a miracle cure."

David Body, the solicitor representing vCJD victims and their families, echoed the calls for caution but added: "Anything that is seen to bring an improvement should be welcomed with great enthusiasm.

"It has been ages since there has been any glimmer of hope but there will great caution about being too optimistic."

He added that the treatment would need to be made available in the UK.

Identifying the disease

Even if the cure is found to be successful it could be difficult to implement as there is no test for vCJD on living sufferers - the only test can be done at a post-mortem examination.

The DoH spokesman said government work to develop such a test was continuing as rapidly as possible.

"If you are going to treat someone for a disease you need to be sure that they are suffering from it in the first place," he said.

There would be further delays from clinical trials, licensing and manufacturing, he added.

Prof Prusiner, professor of neurology and biochemistry at the university, won the 1997 Nobel prize for medicine for his work on prions - the infectious agents thought to underlie a number of conditions including vCJD.

-- Anonymous, August 12, 2001