The way HC-110 behaves strongly depends on film. With most films like HP5+ and Plus-X, it's big grain, normal sharpness, nothing special except brighter midtones all compared to D-76 1+1.(posted 8119 days ago)But HC-110 can produce really fine grained image with TMX, and it's so fine grained that the TMX gives you its typical metallic or plastic-like look. Unless that's what you are looking for, you don't want that combination.
TX and HC-110 in 35mm and medium format are not a good combination unless you want to enhance grainy appearance. Gainer formula is probaly a bit finer grained.
I have vitamin-C version of D-76 as I posted here before, and available on film-developer combinations and other parts of my home page. I highly recommend D-76Ad 1+1 for conventional films like HP5+, Tri-X and Plus-X. Accutance version of my vitamin C formula is tweaked for tabular grained films and very slow films. All my formulae on that page are metol-ascorbate based.
I can't comment direct comparison of Gainer's formula and Ilfosol-S, but Gainer's formula is particularly good for TMX in small tanks. For conventional films in 35mm and 6x6cm, I think D-76Ad is better suited. Comparing D-76H and D-76Ad, I see a large difference in terms of grain appearance, and I definitely prefer ascorbate version.