Pyro & Toxicity

I've read some comments here and in Gordon Hutchings book about pyro being toxic. As I'm using it regularly, I'm interested if anyone can tell me about its toxicity. Is it cumulative? I believe it affects the kidneys. It's difficult to estimate how much a careful user might absorb if he/she is a frequent user, but how much do you need to cause an effect? Is the effect permanent? Is it carcinogenic? Any help would be appreciated.

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